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Captopril (rINN) is an angiotensin-converting enzyme (ACE) inhibitor used for the treatment of hypertension and some types of congestive heart failure. Captopril was the first ACE inhibitor developed and was considered a breakthrough both because of its novel mechanism of action and also because of the revolutionary development process.
Specification:
|
Product name |
Captopril |
|
Appearance |
White or almost white crystalline powder |
|
Solubility |
Freely soluble in water,in methylene chloride and in methanol. It dissolves in dilute solutions of alkali hydroxides. |
|
Identification |
Ir spectrum conformod tothat of captopril crs |
|
Appearance of solutions |
Clear and colorless |
|
Melting range |
Between 104°c and 110°c |
|
Specific optical rotation |
-125° to -130° |
|
Related substance Ampa Captopril disulfide Single unknown impurity Tctal unknown impurities |
Not more than 0.2% Not more than 1.0% Not more than 0.2% Not more than 0.5% |
|
Heavy metals |
Not more than 0.003% |
|
Loss on drying |
Not more than 1.0% |
|
Sulphated ash |
Not more than 0.2% |
|
Assay |
97.5%~102.0% calculated on anhydrous basis |
Packaging details:
|
Packaging details: |
25kg/drum with double plastic bags inside; packed in a cardboard drum or fiber HDPE drum. |
|
Storage: |
Stored in a clean, cool, dry area; keep away from moisture and strong, direct light/heat |
|
Shelf Life: |
5 years if sealed and store away from direct sun light. |
