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Hydrochlorothiazide is frequently used for the treatment of hypertension, congestive heart failure, symptomatic edema, diabetes insipidus, renal tubular acidosis. It is also used for the prevention of kidney stones in those who have high levels of calcium in their urine.
· Product Name: Hydrochlorothiazide
· Formula:C7H8ClN3O4S2
· Molecular Weight:297.73
· CAS No.:58-93-5
· Density:1.693 g/cm3
· Melting Point:273 °C
· Boiling Point:577 °C at 760 mmHg
· Flash Point:577 °C at 760 mmHg
Specification:
|
Contents |
Specification |
Results |
|
Characteristics |
White or almost white Crystalline powder |
complies |
|
Solubility |
Very slightly soluble in water, slightly soluble in alcohol, Soluble in acetone and dilute solutions of alkalines hydroxides |
complies |
|
Coalition Band |
266°Cto270°C,with decomposition |
complies |
|
Identification |
Meets the requirements |
complies |
|
Acidity or alkalinity |
≤0.4ml |
0.2ml |
|
Chloride |
≤ 0.03% |
< 0.01% |
|
Selenium |
< 0.003% |
< 0.003% |
|
Heavy metal |
< 0.001% |
< 0.001% |
|
Residue on ignition |
≤0.1% |
0.03% |
|
Related Substances a)Any peak b)Sum of peak |
≤0.5% ≤1.0% |
0.28% 0.35% |
|
4-Amino-6-chloro-1.3- -Benzenedisulfonamide |
< 1% |
0.39% |
|
Loss on drying |
≤ 0.5% |
0.04% |
|
Organic volatile impurities |
Meets the requirements |
Complies |
|
Assay |
98.0-102.0%(on the dried basis sub) |
99.58 % |
|
Conclusion: It complies with the requirements of the USP32. |
||
Packaging details:
|
Packaging details: |
25kg/drum with double plastic bags inside; packed in a cardboard drum or fiber HDPE drum. |
|
Storage: |
Stored in a clean, cool, dry area; keep away from moisture and strong, direct light/heat |
|
Shelf Life: |
5 years if sealed and store away from direct sun light. |
