- E-mail : info@ggolden.co.uk
Propranolol is a medication of the beta blocker type.It is used to treat high blood pressure, a number of types of irregular heart rate, thyrotoxicosis, capillary hemangiomas, performance anxiety, and essential tremors.It is used to prevent migraine headaches, and to prevent further heart problems in those with angina or previous heart attacks. It can be taken by mouth or by injection into a vein.
Specification:
|
Items |
Specifications |
Results |
|
Appearance |
A white or almost white powder |
Conforms |
|
Solubility |
Soluble in water and in ethanol (96%) |
Conforms |
|
Identification |
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|
A |
Melting point : 163°C~166°C |
164.0~164.5°C |
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B |
Examine by infrared absorption spectrophotometry, comparing with the spectrum obtained with propranolol hydrochloride CRS. |
Conforms |
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C |
Examine by thin-layer chromatography. The principal spot in the chromatogram obtained with the test solution is similar in position, colour and size to the principal spot in the chromatogram obtained with the reference solution. |
Conforms |
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D |
It gives reaction(a) of chlorides |
Conforms |
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Tests |
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Appearance of solution |
The solution is clear and not more intensely coloured than intensity 6 of the range of reference solutions of the most appropriate colour |
Conforms |
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Acidity or alkalinity |
Add 0.1ml of methyl red solution R and 0.2 ml of 0.01M hydrochloric acid, the solution is red. Add 0.4ml of 0.01 M sodium hydroxide. The solution is yellow. |
Conforms |
|
Related substances |
Any impurity NMT 0.1% |
0.03% |
|
The sum of all impurities NMT 0.4% |
0.21% |
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|
Heavy metals |
NMT 20ppm |
Conforms |
|
Loss on drying |
NMT 0.5% |
0.11% |
|
Sulphated ash |
NMT 0.1% |
0.08% |
|
Residual solvents |
A: ethanol: NMT 5000ppm B: Xylene: NMT 2170ppm |
Conforms Conforms |
|
Assay |
99.0%~101.0% |
99.3% |
Packaging details:
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Packaging details: |
25kg/drum with double plastic bags inside; packed in a cardboard drum or fiber HDPE drum. |
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Storage: |
Stored in a clean, cool, dry area; keep away from moisture and strong, direct light/heat |
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Shelf Life: |
5 years if sealed and store away from direct sun light. |
