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Tenofovir is a selective antiretroviral agent which functions as a HIV reverse transcriptase inhibitor. Studies indicate that Tenofovir shows a low cytotoxicity in human cell types compared to other nucleoside reverse transcriptase inhibitors.
It is known that HIV replicates its double stranded DNA via reverse transcriptase and then the DNA is integrated into the hosts chromosomes. Tenofovir functions by inhibiting the replication of this DNA. Furthermore, studies suggest that Tenofovir prevents cytoxicity in SIV-infected C- 8166 cells in vitro.
Specification:
|
Items Tested |
Specification |
Result |
|
Characters |
White or almost white crystalline powder |
Confirms |
|
Assay (HPLC) |
99.0~101.0% |
Confirms |
|
Melting Point |
276~280°C |
Confirms |
|
Specific Rotation |
-19.3°~-23.7° |
Confirms |
|
Loss on drying |
Not more than 5.0% |
Confirms |
|
Water solubility |
13.4mg/mL(25°C) |
Confirms |
|
Single Impurity |
Not more than 0.2% |
Confirms |
|
Total Impurity |
Not more than 0.5% |
Confirms |
|
Conclusion |
Conforms USP32 |
|
Packaging details:
|
Packaging details: |
25kg/drum with double plastic bags inside; packed in a cardboard drum or fiber HDPE drum. |
|
Storage: |
Stored in a clean, cool, dry area; keep away from moisture and strong, direct light/heat |
|
Shelf Life: |
5 years if sealed and store away from direct sun light. |
